A recent study from the International Journal of Pharmaceutical Sciences suggests that sildenafil, sold under the brand name Viagra, may be safe when taken on a regular basis and as an alpha-blocker. The research also suggests that Viagra might have a better effect than regular sildenafil, in comparison to other drugs used for erectile dysfunction. Sildenafil is the generic name of Viagra. It is a medication used for treating erectile dysfunction in men. Viagra is available in a 50 mg dosage.
The drug is marketed by Pfizer Inc. and is available in the United States under the brand name of generic sildenafil citrate. It is also marketed by Bayer AG and GlaxoSmithKline. It is available in the United States in doses of 25 mg, 50 mg, and 100 mg. Sildenafil is a nitrate drug. The use of this drug as an alpha-blocker has been linked to increased blood pressure and erectile dysfunction, which are conditions that can occur when blood vessels tighten, leading to erectile dysfunction. It is not known if sildenafil was responsible for the erectile dysfunction that is associated with the use of the drug. It is also not known if sildenafil was responsible for the heart attack that is linked to the use of sildenafil.
This study was conducted at the University of Washington School of Pharmacy and the Department of Pharmacy Medicine at the University of Washington. The study was conducted to evaluate the safety and efficacy of sildenafil in a randomized, double-blind, placebo-controlled study. Patients who took sildenafil at the beginning of the study for the treatment of erectile dysfunction, the end of the study, or the beginning of the study were enrolled. The study was conducted in accordance with the approved procedures of the University of Washington School of Pharmacy.
The study was approved by the Institutional Review Board of the University of Washington. The trial was registered at https://clinicaltrials.gov. The findings of the study were reported in a press release posted on the website of the Drug Safety and Adverse Reactions Reporting System (DRARS) at the American Pharmacists Association.The study protocol is presented in Figure 1. Sildenafil was administered via intramuscular (IM) injections into the thigh, abdomen, or upper arm (UP). Patients received sildenafil at a dose of 25 mg (50 mg/day) or 100 mg (25 mg/day) orally once daily. Patients were observed for 24 weeks. Patients were assessed by a blinded pharmacist and recorded on a 1-point scale ranging from “1-3” to “4-6.” All patients were evaluated for side effects.Figure 1: Study protocol.
Study design.This was a randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety and efficacy of sildenafil at 25 mg (50 mg/day) or 100 mg (25 mg/day) orally once daily in male patients with erectile dysfunction. Patients were randomly assigned to sildenafil or placebo group at baseline, treatment, and at the end of the study, and at 4-6 weeks, to receive sildenafil at 25 mg, 50 mg, or 100 mg daily. Patients were monitored for adverse events, and they were instructed to report any signs of adverse events. Data were collected by using a structured interview. The patients were informed about the study and asked to record any questions they were asked about their treatment with sildenafil. Patients were evaluated by using the DRARS. The patient information sheet was provided in PDF format. The researchers were not involved in the study.
Figure 2: Study sample.
A total of 705 patients were recruited for the study. After exclusion of patients from the placebo group, the total sample size was calculated to be 18. The primary outcome was the proportion of patients who experienced adverse events or were considered non-serious. The secondary outcomes included the proportion of patients experiencing erectile dysfunction (ED) in the group that received sildenafil as compared to placebo, the incidence of adverse events and its complications. The analysis of the data was performed by using a data processing software. The study was approved by the Human Research Ethics Committee of the University of Washington School of Pharmacy and the Department of Pharmacy Medicine at the University of Washington. The data was collected in a blinded fashion. The patients were observed for 24 weeks.
Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.
Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors
Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.
Consult your doctor if you experience:
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Note: Other medications can affect how Sildenafil is processed in your body, potentially impacting its effectiveness. These include azole antifungals (such as itraconazole or ketoconazole), macrolide antibiotics (such as clarithromycin or erythromycin), HIV protease inhibitors (such as saquinavir), mifepristone, rifampin, and ritonavir.
Combining Sildenafil with other medications for erectile dysfunction (ED) or pulmonary hypertension, such as tadalafil or vardenafil, is harmful.
esarina 5mg tabletsUse Sildenafil exactly as directed. If using tadalafil or vardenafil, consult your doctor. For ketoconazole, use Sildenafil at a dose of 5mg.
Mirtazapine and sildenafil can interact with Sildenafil. When this medication is used at higher doses (e.g., 40 or 100mg, respectively, to treat pulmonary hypertension), it may cause your blood pressure to drop suddenly higher than what it should be supposed to be. This can lead to dizziness or fainting. Therefore, avoid using Sildenafil with these medications if you have tachycardia, fainting, and low blood pressure.
Never take Sildenafil with nitrates like isosorbide dinitrate or nitroglycerin that are also in Sildenafil. Nitrates are also used to treat pulmonary hypertension.
take 2 tablets at a time. Do not exceed the recommended dose.arger doses can cause your blood pressure to drop more quickly, increase your risk for serious side effects, or — if you know — you may feel dizzy or faint, often dizzy or lightheaded, get chest pain that is severe or lasts for a few minutes. If this happens, call your doctor immediately or get emergency medical treatment. Do not increase your blood pressure more often than prescribed. Your doctor will provide a dosage and can adjust it as needed.
When using Sildenafil at a lower dose (e.g., 1 or 2 10mg tablets per day), you may experience side effects, although not everybody gets them. The following shouldn’t take into account Sildenafil’s full effects.
Common side effects of Sildenafil use:
Rare side effects:
If you have a history of liver disease, fungal disease, or blood circulation problems, schedule aetic stimulation tests may be required. Do not take Sildenafil with nitrates like isosorbide dinitrate or nitroglycerin.
take with calcium or magnesium signaling of PDE5 inhibitor.VIDEO
Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.
under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.
The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.
Medication | Onset | Duration |
---|---|---|
Sildenafil (Viagra) | 30-60 minutes | 4-5 hours |
The most common side effects consist of the following:
If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:
Some patients may experience serious side effects; if you experience these, get medical help right away. Serious side effects include:
We offer more than just lower prices on
sildenafil in Canada and free shipping. Some patients experience side effects that are not listed. If you have any concerns regarding Viagra, contact your physician.
Take note: This medicine is available only with a valid doctor's prescription.This medicine is also available in a generic drug called sildenafil citrate.